TELEX HEBDOMADAIRE NR 186 DU 12 OCTOBRE 1984 ADRESSE A L'ENSEMBLE DES DELEGATIONS EXTERIEURES ET BUREAUX DE PRESS ET D'INFORMATION INDEPENDANTS DANS LES PAYS TIERS = WEEKLY MEMO NO. 186 ON OCTOBER 12, 1984 TO FOREIGN DELEGATIONS AND PRESS BUREAUS OF THIRD COUNTRIES

Inhibitory activities against BoNT/A LC and holotoxin in proteolytic and cell-based assay for all tested compounds; fluorescence and UV–vis spectra for determination of 16 binding to HSA and AGP; ligand interaction diagrams, docking scores, and docking–in vitro inhibitory activity correlations; spectral and analytical data for all synthesized compounds; detailed procedures for the determination of the HPLC purity.Supporting information I for: Konstantinović, J. M., Kiris, E., Kota, K. P., Kugelman-Tonos, J., Videnović, M., Cazares, L. H., Terzić-Jovanović, N., Verbić, T., Anđelković, B. D., Duplantier, A. J., Bavari, S.,& Šolaja, B. (2018). New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model. Journal of Medicinal Chemistry, American Chemical Society (ACS)., 61(4), 1595-1608. [https://doi.org/10.1021/acs.jmedchem.7b01710]The published version of the article: [https://cer.ihtm.bg.ac.rs/handle/123456789/2325]The peer-reviewed version of the article: [http://cer.ihtm.bg.ac.rs/handle/123456789/2935]Additional supporting information (NMR spectra and HPLC purity spectra of all tested compounds): [https://cer.ihtm.bg.ac.rs/handle/123456789/4516]Molecular formula strings and additional data: [https://cer.ihtm.bg.ac.rs/handle/123456789/4517

Supporting Information II for: "New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model"

NMR spectra and HPLC purity spectra of all tested compoundsSupporting information II for: Konstantinović, J. M., Kiris, E., Kota, K. P., Kugelman-Tonos, J., Videnović, M., Cazares, L. H., Terzić-Jovanović, N., Verbić, T., Anđelković, B. D., Duplantier, A. J., Bavari, S.,& Šolaja, B. (2018). New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model. Journal of Medicinal Chemistry, American Chemical Society (ACS)., 61(4), 1595-1608. [https://doi.org/10.1021/acs.jmedchem.7b01710]The published version of the article: [https://cer.ihtm.bg.ac.rs/handle/123456789/2325]The peer-reviewed version of the article: [http://cer.ihtm.bg.ac.rs/handle/123456789/2935]Additional supporting information: [https://cer.ihtm.bg.ac.rs/handle/123456789/4515]Molecular formula strings and additional data: [https://cer.ihtm.bg.ac.rs/handle/123456789/4517

Supplementary data for the article: Konstantinović, J.; Kiris, E.; Kota, K. P.; Kugelman-Tonos, J.; Videnović, M.; Cazares, L. H.; Terzić Jovanović, N.; Verbić, T. Ž.; Andjelković, B.; Duplantier, A. J.; et al. New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model. Journal of Medicinal Chemistry 2018, 61 (4), 1595–1608. https://doi.org/10.1021/acs.jmedchem.7b01710

Supplementary material for: [https://doi.org/10.1021/acs.jmedchem.7b01710]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2099

Model based dynamics analysis in live cell microtubule images

Background: The dynamic growing and shortening behaviors of microtubules are central to the fundamental roles played by microtubules in essentially all eukaryotic cells. Traditionally, microtubule behavior is quantified by manually tracking individual microtubules in time-lapse images under various experimental conditions. Manual analysis is laborious, approximate, and often offers limited analytical capability in extracting potentially valuable information from the data. Results: In this work, we present computer vision and machine-learning based methods for extracting novel dynamics information from time-lapse images. Using actual microtubule data, we estimate statistical models of microtubule behavior that are highly effective in identifying common and distinct characteristics of microtubule dynamic behavior. Conclusion: Computational methods provide powerful analytical capabilities in addition to traditional analysis methods for studying microtubule dynamic behavior. Novel capabilities, such as building and querying microtubule image databases, are introduced to quantify and analyze microtubule dynamic behavior

HEALTH RISK ASSESSMENT OF TRACE ELEMENTS IN MEDICINAL PLANTS CONSUMED AS MEDICINE AND FOOD IN RIZE, TURKEY

WOS: 000550823500046Trace element (Cd, Pb, Ni, Fe, Zn, Cu, Cr, Co and Mn) levels were measured using Inductively Coupled Plasma Optical Emission Spectrometry (ICP OES) in twelve different medicinal plants consumed as medicine and food in Rize, Turkey in the study. Medicinal plants were supplied from local herbalists in November 2018. the concentrations of trace elements in the medicinal plants varied between 0.12 and 0.62 mg kg(-1) for Cd, 0.12 and 1.87 mg kg(-1) for Pb, 0.25 and 3.37 mg kg(-1) for Ni, 20.47 and 342.82 mg kg(-1) for Fe, 8.61 and 67.79 mg kg(-1) for Zn, 0.62 and 10.11 mg kg(-1) for Cu, 0.12 and 2.87 mg kg(-1) for Cr and 3.87 and 302.75 mg kg(-1) for Mn. the concentrations of Co were determined to be 0.12 and 0.25 mg kg(-1) for two plants. the concentrations of trace elements obtained in this study were compared with the WHO permissible limits and the trace element levels obtained in relevant studies in the literature. Moreover, Pearson's correlation coefficients were used to evaluate the relationship between the trace elements. the hazard quotient (HQ) and hazard index (HI) values were calculated to examine the non-carcinogenic health risks from individual element and combined elements for an adult due to medicinal plant consumption. the HQ and HI values for the trace elements in the medicinal plants were found to be lower than 1. Therefore, the medicinal plants examined in this study do not pose a risk to human health in terms of the trace elements

Kiris 2015

<p>Data for Figures</p

Sediment distribution coefficients (K-d) and bioaccumulation factors (BAF) in biota for natural radionuclides in eastern Black Sea coast of Turkey

WOS: 000480374600074y Germanium (HPGe) detector was used to measure natural (Ra-226, Th-232 K-40) radioactivity levels in sediment and seawater samples, and soft tissues of Mediterranean mussels (Mytilus galloprovincialis) of three different sizes, collected from twelve different stations along the coast of Giresun, Trabzon, Rize and Artvin provinces in Eastern Black Sea Region. the average activity concentrations of the sediment and seawater samples collected were 12.65 Bq kg(-1) and 3.57 mBq L-1 for Ra-226, 14.25 Bq kg(-1) and 4.01 mBq L-1 for Th-232 and 294.8 Bq kg(-1) and 317.8 mBq L-1 for K-40, respectively. the activity concentrations in soft tissues of three different sized mussel samples altered from 2.45 to 9.59 Bq kg(-1) for Ra-226 2.22-8.59 Bq kg(-1) for Th-232 and 251.9-382.1 Bq kg(-1) for K-40. Moreover, sediment distribution coefficients(K-d) and bioaccumulation factors (BAF(w) and BAF(s)) in the mussel samples were calculated. While the bioaccumulation of Ra-226 and Th-232 from seawater to mussel was observed, the bioaccumulation K-40 was observed from sediment to mussel. the ratio of the average concentration of radionuclides in large-sized mussels to that in water and sediment is greater as compared with smaller mussels. Although there were statistically differences (p 0.05).Scientific and Technological Research Council of Turkey (TUBITAK) (CAYDAG)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [11 3Y148]The data in this study were produced from the PhD thesis of Erkar Kins (Thesis No: 427802). This work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (CAYDAG, Project No: 11 3Y148)

Determination of radioactivity levels and heavy metal concentrations in seawater, sediment and anchovy (Engraulis encrasicolus) from the Black Sea in Rize, Turkey

Sirin, Murat/0000-0001-6864-752XWOS: 000399507600072PubMed: 28081960Seawater, sediment and fish (anchovy) samples consumed in the Rize province of the Eastern Black Sea region of Turkey were collected from five different stations. the radioactivity levels (Ra-226, Th-232. K-40 and Cs-137) were determined in all the samples using a high-purity germanium detector. While Ra-226, Th-232 and (4)0(K) radionuclides were detected in all samples, the radionuclide concentration of C-137.s, except for the sediment samples (mean activity is 9 +/- 1.4 Bq kg(-1)), was not detected for the seawater and fish samples. the total annual effective dose rates from the ingestion of these radionuclides for fish were calculated using the measured activity concentrations in radionuclides and their ingested dose conversion factor. Also, the concentrations of some heavy metals in all the samples were determined. the activity and heavy metal concentration values that were determined for the seawater, sediment and fish samples were compared among the locations themselves and with literature values. (C) 2017 Elsevier Ltd. All rights reserved

Terminal syringomyelia in association with the tethered cord syndrome

OBJECTIVE: With the increasing use of magnetic resonance imaging, terminal syringomyelia (segmental cystic dilation of the caudal one-third of the spinal cord) in association with the tethered cord syndrome has become an appreciable finding. This study attempted to define the clinical significance of this associated pathological condition by describing its clinical and radiological characteristics and its contribution to the clinical status of patients with tethered spinal cords